 2019 - 2020 | |||||||||||||||||||||||||||||
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| 0351-3203 | Physical Organic Chemistry | ||||||||||||||||||||||||||||
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| FACULTY OF EXACT SCIENCES | |||||||||||||||||||||||||||||
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University credit hours: 2.0
Course description
- Thermodynamics and kinetics of organic reactions. Methods to study mechanisms of organic reactions. Kinetic isotope effect. Linear free energy relationships (Hammett, Brown, Tafts, etc.)
- Solvent effect on chemical reactivity. Solvation properties and scales. Equation of Grunwald & Weinstein, Z-factor, ET(30). Polar aprotic solvents and their influence on chemical reactivity. Phase-transfer catalysis. Hydrophobic effects
- Reactive intermediates- carboanions. pKa of C-H acids. Stability and reactivity of carboanions. NMR characterization and ion-pairing of simple organometallic derivatives
- Reactive intermediates- carbocations. Generation and stability of carbocations. Rearrangements involving carbocations. Classic and non-classic carbocations