The course covers the analytical and computational methods to model and simulate mechanical behavior of materials taking their microstructure into account. Multiscale modelling from atomistic level to macrolevel allows to describe and predict effective properties of materials. Nowadays it is highly important for nanostructures, composites, metamaterials, and foams. Also, multiscale methods are highly important for study of fracture and dislocation mechanics, plasticity. This course allows to understand some general concepts and use them to study different problems in mechanics of solids.