I.Introduction: Biopolymer components- amino acids, nucleic acids, lipids, sugars

(4) ch. 1, (6) ch. 2, (3) ch. 1

II.Forces and interactions in biophysics (EM, VDW, hydration, thermal/entropic, hydrophobic, covenant and H-bonds)

(1) ch 1-2 (also ch. 3-9), (4) ch. 2

III.Salt solutions - PB + PB approximations. Debye Huckel theory, ionization and phase separation

(2) ch 6, (4) ch. 9, (3) ch. 9, (1) ch. 14

IV.Charged surfaces - Gouy Chapman, correlation effects, fluctuation

(1) ch. 14, (2) ch 4-6

V.Counter ions condensation, Manning condensation, DLVO theory

(1) ch. 13,14,21 (5) ch. 5.2

VI.Interacting membranes and complexes - elastic energy and phase behavior

(1) ch. 20-21 (3) ch. 11 ,(4) ch.10, (2) ch. 4,5, (5) ch. 7

VII.Random walks, diffusion and elasticity of biopolymers

(4) ch. 8, (3) ch. 8 -10, (2) ch. 3, (3) ch. 9, (6) ch. 6

VIII.Polyelectrolytes - flexibility and rigidity

(4) ch. 9, (3) ch. 9

IX.DNA condensation (with ions, lipids, histones, viruses etc)

(4) ch. 16, (3) ch. 10

X.Cytoskeleton proteins - self-assembly, interactions, phase behavior

(2) ch. 8

XI.Biophysical structural techniques: Microscopy, FRET, NMR, rheology, X-ray scattering and diffraction, neutron scattering, SPM, EM, SFA, simulation (MC, MD)

(4) ch. 12,13, (2) ch 14-16

Texts Books:

1. Israelachvilli - Intermolecular and Surface Forces
2. Poon and Andelman - Soft-Matter Physics in Molecular and Cell Biology
3. Phillips - Physical Biology of the Cell
4. Waigh – Applied Biophysics
5. Witten & Pincus – Structured fluids

Additional books:

1. Nelson, Biological Physics
2. Dill & Bromberg - Molecular Driving Forces - Ch.22-33
3. Fraser - The New Physics - ch. 16
4. Evans & Wennerstrom - The colloidal Domain
5. Atkins & de Paula - Physical Chemistry