D:\Inetpub\shared\yedion\syllabus\03\2019\0365\0365456501_desc.txt

Topics in Statistical Genetics:

The goal of this course is to introduce some of the major topics in Genetics, and gain a statistical perspective on them.
We will start with a brief introduction to Genetics concepts, and gradually start elaborating on statistical aspects of the questions that come up. As needed, we will introduce relevant areas of statistics in some detail.
The final grade will be based on a combination of homework, a final take home exam, and possibly a class presentation.
Tentative topics list (each topic 1-2 weeks):

·         Introduction to Genetics and quantitative Genetics

·         Mutation models: stochastic processes; estimation from data

·         Phylogenetic analysis: algorithms and inference

·         Human population genetics: statistical inference about human history

·         Estimation of ancestry

·         Principal component analysis in Genetics

·         Genome-wide association studies (GWAS)

·         Major public data sources like HapMap, 1000Genome project and their analysis

·         Estimation of heritability of disease