Title: Selected Topics in Synthetic Organic and Bioorganic Chemistry
Prof. Moshe Portnoy and Prof. Doron Shabat
2 Credit points
Prerequisite: Organic Chemistry 1, Organic Chemistry 2
Course Objectives/Goals: Introduce students to methodologies of synthetic organic and bioorganic chemistry that are not covered by current undergraduate or graduate programs:
Familiarize students with the methodology of solid-phase organic synthesis
Acquaint students with modern methods of chemical bioconjugation
Introduce students to useful organic reactions, broadly applied in modern organic and bioorganic synthesis, that are not included in prerequisite courses.
Course format: In the first part of the course the lecturers will present to students the methodologies of solid-phase organic synthesis and chemical bioconjugation in a standard lecture format.
In the second part of the course each participating students will chose an organic reaction that is: 1) synthetically useful and broadly applied in organic/bioorganic synthesis; 2) not included in the basic courses Organic Chemistry 1 and Organic Chemistry 2, or in advanced courses Principles of Organic Synthesis and Selected Topics in Organometallic Chemistry. The student will prepare a brief presentation of the reaction that will include the typical substrates, conditions, reagents or catalysts, advantages, as well as mechanism, applications in multistep synthesis, stereochemical aspects, etc. Additionally, the student will provide a list of homework problems, associated with the chosen reaction, but not explicitly covered in the presentation. The problems will be discussed jointly at the next meeting and participation of the students in their solution will be translated into part of their final grades.
Grade: Presentation + Participation in Solution of Homework Problems.